picture of 1921 straw house
1921

Busaburo Otsuka establishes Otsuka ...

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picture of 1921 straw house

1921

Busaburo Otsuka establishes Otsuka Seiyaku Kogyo-bu, a factory manufacturing chemical raw materials in Tokushima Prefecture, Japan. Back then, the company had just ten employees.
Image of 1935 Otsuka kalium Bromatum
1935

The company's business now incl...

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Otsuka 1935 Kalium Bromatum

1935

The company's business now includes raw materials for use in pharmaceutical products and the company name was changed to Otsuka Pharmaceutical Factory.
2 I.V Solution Bottles
1946

Busaburo Otsuka's eldest son, M...

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2 I.V solution Bottles

1946

Busaburo Otsuka's eldest son, Masahito, takes over the company and starts selling I.V. solutions to hospitals throughout Japan.
Smiling woman holding Otsuka first over the counter ointment
1953

The company continues to diversify

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Smiling woman holding Otsuka first over the counter ointment

1953

The company continues to diversify and, helped by the use of innovative advertisements on vehicles, TV and radio, Otsuka Pharmaceutical Factory launches its first over-the-counter drug, Oronine Ointment, which is still available today.
Man holding a crate of a carbonated nutritional drink
1964

Otsuka Pharmaceutical Co., Ltd. is ...

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Man holding a crate of a carbonated nutritional drink

1964

Otsuka Pharmaceutical Co., Ltd. is established and has since created a global business based on pharmaceuticals and ‘nutraceuticals’  (a combination of the words  ‘nutrition’ and ‘pharmaceuticals’ used to describe foods and beverages with scientific evidence of their benefit in day-to-day health maintenance). ORONAMIN C, a carbonated nutritional drink was the first of the neutraceuticals. Popular neutraceuticals launched in the 1980s include Pocari Sweat, an electrolyte replenishment beverage, and Calorie Mate, an energy-giving food supplement.

Image of Akihito Otsuka aged 36
1976

Akihiko Otsuka, aged just 36, is ap...

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Image of Akihito Otsuka aged 36

1976

Akihiko Otsuka, aged just 36, is appointed president of Otsuka Pharmaceutical Co., Ltd. and Otsuka Foods Co., Ltd. and subsequently develops the pharmaceutical, neutraceutical and foods businesses by focusing on original products.
satellite image of Europe
1979

Otsuka opens its first European ope...

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Satellite image of Europe

1979

Otsuka opens its first European operation in Spain and in 2016 has established facilities in Germany, UK, Scandinavia, Germany, France, Switzerland, Italy and the Nordic region. Otsuka Pharmaceutical Europe Ltd. (OPEL) was set up in 1998 to support the European operations.
One red and one blue box of pills
1980

Otsuka Pharmaceutical Co., Ltd. lau...

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One red and one blue box of pills

1980

Otsuka Pharmaceutical Co., Ltd. launches its first originally-developed medications: a high blood pressure product to treat angina pectoris and arrhythmia, and a bronchodilator.
7 cans of Pocari Sweat
1980

Pocari Sweat is launched in Japan a...

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7 cans of Pocari Sweat

1980

Pocari Sweat is launched in Japan as a health drink. It is designed to help people to rehydrate after perspiring while playing sports, working, or taking a hot bath. It can also hydrate you first thing in the morning. Pocari Sweat is now also available in the Middle East, Southeast Asia, and East Asia.

Otsuka Maryland Office of Clinical Research
1985

Maryland Office of Clinical Researc...

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Otsuka Maryland Office of Clinical Research

1985

Maryland Office of Clinical Research, America’s initial Japnese pharmaceutical research base was established in Rockville, Maryland. This was the beginning of the truly international drug research organization by Otsuka and the company would go on to support an international clinical development network that spanned Japan, the U.S., and Europe.

A bunch of Blueberries
1986

Otsuka Group acquires Ridge Vineyar...

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A bunch of Blueberries

1986

Otsuka Group acquires Ridge Vineyards in California. Today, the vineyard is known for producing some of the highest quality wines in the world. When Akihiko Otsuka told his father Masahito (the son of the founder of Otsuka) that he wanted to purchase Ridge Vineyards, his outraged father replied that it would be absurd for a company in the health business to buy a company that sells alcohol. But Akihiko quoted the old saying, ‘sake (alcohol) is the chief of all medicines,’ and persuaded his father to approve the deal.
2 boxes of Pleetal
1988

PLETAL® (cilostazol) is launched in...

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2 boxes of Pleetal

1988

PLETAL® (cilostazol),  is launched in Japan. (Pletal received FDA approval in the U.S. in 1999).

 

Otsuka America Pharmaceutical, Inc.
1989

Otsuka America Pharmaceutical, Inc....

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Otsuka America Pharmaceutical, Inc.

1989

Otsuka America Pharmaceutical, Inc. (OAPI) is established to oversee all pharmaceutical and medical device commercial activities in the United States.
Crystal Geyser water bottle
1990

The Crystal Geyser Water Company jo...

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Crystal Geyser water bottle

1990

The Crystal Geyser Water Company joins the Otsuka Group. The California-based company pioneered flavored sparkling water and today provides health-conscious consumers with natural alternatives to sugared or artificially sweetened soft drinks.
graphic of BreathTek
1996

FDA approves BreathTek® UBT test fo...

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graphic of BreathTek

1996

FDA approves BreathTek® UBT for adults

Large room with ornately painted ceiling
1998

The Otsuka Museum of Art opens to c...

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Large room with ornately painted ceiling

1998

The Otsuka Museum of Art opens to commemorate Otsuka Group’s 75th anniversary. The museum, located in the mountains of Naruto National Park, now houses a collection of more than 1,000 pieces of Western art along its 4 km exhibition course and is the world’s only ceramic art museum.  Among the museum’s collections are two reproductions, facing one another, of Leonardo da Vinci’s The Last Supper, one before and one after its restoration, as well as an extraordinary, full-size reproduction of the Sistine Chapel Ceiling.
Akihito Otsuka shaking hands wth ?
2002

FDA approves antipsychotic drug ABI...

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Akihito Otsuka shaking hands wth ?

2002

FDA approves antipsychotic drug ABILIFY® (aripiprazole), co-developed and co-promoted with Bristol-Myers Squibb.

image of soy joy product
2006

Otsuka Pharmaceutical Co., Ltd. rel...

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image of soy joy product

2006

Otsuka Pharmaceutical Co., Ltd. releases SOYJOY, a fruit and soybean bar made using whole soybean flour. It was the first product under the Otsuka Group’s Soylution (soy+solution) business, marketing soybeans as a way to help resolve health and environmental challenges. Initially released in Japan, the United States and China, SOYJOY is now sold in 11 countries and regions around the world.

3D see-through Brain
2007

Otsuka Pharmaceutical Development &...

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3D see-through Brain

2007

Otsuka Pharmaceutical Development & Commercialization, Inc. (OPDC) is established in the U.S. to research and develop products and solutions to treat disorders in the neuroscience, oncology, and cardio-renal therapeutic areas. OPDC serves as a base for international expansion strategy and pharmaceutical clinical development worldwide.
IV Busulflex (busulfan) injection
2008

Otsuka acquires IV BUSULFEX® (busul...

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IV Busulflex (busulfan) injection

2008

Otsuka acquires IV BUSULFEX® (busulfan).

box of Samsca tablets
2009

FDA approves SAMSCA® (tolvaptan)

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box of Samsca tablets

2009

FDA approves SAMSCA® (tolvaptan).

Akihiko Otsuka  ringing Tokyo stock exchange bell
2010

Otsuka Holdings was listed on the F...

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Akihiko Otsuka  ringing Tokyo stock exchange bell

2010

Otsuka Holdings was listed on the First Section of the Tokyo Stock Exchange (the section for the for the largest, most successful ‘blue chip’ companies).
Canadian Flag
2010

Otsuka Canada Pharmaceutical Inc. i...

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Canadian Flag

2010

Otsuka Canada Pharmaceutical Inc. is established as a subsidiary of Otsuka America Pharmaceutical, Inc. to commercialize products in Canada.
Otsuka Celebrates its 90th anniversary
2011

Otsuka Group celebrated its 90th an...

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Otsuka Celebrates its 90th anniversary

2011

Otsuka Group celebrated its 90th anniversary.
Japanese and Canadian delegates meet
2011

Global alliance agreement with the ...

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Japanese and Canadian delegates meet

2011

Global alliance agreement with the Danish company H. Lundbeck A/S to work towards a new generation of CNS drugs.
BreathTek breath bags
2012

FDA approves BreathTek UBT as the f...

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BreathTek breath bags

2012

FDA approves BreathTek® UBT as the first breath test for use in children ages 3 to 17 years to detect H. pylori bacterial infections, responsible for chronic stomach inflammation (gastritis) and ulcers.
2013

Otsuka and Lundbeck begin marketing...

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2013

Otsuka and Lundbeck begin marketing ABILIFY MAINTENA (aripiprazole), an extended-release injection formulation, in the U.S.

Abilify Maintena for extended release injectable suspension
2013

ABILIFY MAINTENA (aripiprazole)

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Abilify Maintena for extended release injectable suspension

2013

Astex pharmaceuticals
2013

Otsuka acquires Astex Pharmaceutica...

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Astex pharmaceuticals

2013

Otsuka acquires Astex Pharmaceuticals, Inc., a leader in innovative drug discovery and development with a focus on cancer and diseases of the central nervous system.
Dacogen decitabine for injection
2014

Otsuka acquires rights from Eisai I...

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Dacogen decitabine for injection

2014

Otsuka acquires rights from Eisai Inc. to develop and market DACOGEN® (decitabine) in the US, Canada and Japan.

 

Avanir pharmaceuticals
2015

Otsuka acquires Avanir Pharmaceutic...

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Avanir pharmaceuticals

2015

Otsuka acquires Avanir Pharmaceuticals, Inc., with the aim of building upon Otsuka’s presence in neuroscience and core business presence in the CNS field. In the U.S., Avanir markets NUEDEXTA® (dextromethorphan hydrobromide and quinidine sulfate).

 

Proteus Digital Health ingestible sensor on a single tablet
2015

FDA allows substantive review of Ne...

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Proteus Digital Health ingestible sensor on a single tablet

2015

FDA allows substantive review of New Drug Application (NDA) for the combination product of ABILIFY® (aripiprazole) embedded with a Proteus Digital Health ingestible sensor in a single tablet. This is the first time an FDA-approved medication, ABILIFY® (aripiprazole) has been combined and submitted for approval with a sensor within the medication tablet (the Proteus ingestible sensor).
2015

FDA approves REXULTI® (brexpiprazol...

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2015

FDA approves REXULTI® (brexpiprazole) tablets.

 

2016

ODH, Inc. established as a new comp...

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2016

ODH, Inc. established as a new company to provide innovative data analytics solutions that aspire to leverage technology and clinical expertise to transform the delivery and economics of behavioral healthcare.

Otsuka in the US

Otsuka’s two U.S. companies carry out research, clinical development and commercialization of Otsuka-discovered and in-licensed products.